Ribosomal Proteins Mutations

Because ribosomes and RPs play such important roles in cells, illnesses caused by RP dysfunction are common. Numerous birth abnormalities and anemia were said to be directly related to ribosomal proteins mutations. Significant evidence suggested that ribosomal gene alterations, particularly those in RPL5, RPS11, RPL19, RPS24, and RPS29, are the root cause of Diamond-Blackfan anemia (DBA). Additionally, many malignancies' prevalence and development are directly correlated with the level of RP expression in malignancy. RPs may make interesting targets for cancer therapy due of their intimate association with cancer.


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