miRNA Antagomir

Creative Biogene's microDOWN™ miRNA antagomir is single-strand miRNA inhibitor carrying the chemically modifications functioning by blocking miRNA regulation of target gene expression efficiently. The strand of the antagomir has 2 phosphorothioates at the 5' end, 4 phosphorothioates, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. Stability of microDOWN™ miRNA antagomir appears to be significantly higher than miRNA inhibitors. It exhibits enhanced cellular uptake, stability and regulatory activity and is recommended for miRNA functional studies in vitro and in vivo.