Hyperthermia Lyme refers to the use of elevated body temperature treatments—either whole-body or localized heating—as an alternative or complementary approach to managing chronic Lyme disease. The theory is that increasing body temperature may weaken or kill the Borrelia bacteria, enhance immune function, and improve antibiotic effectiveness. While some clinics, especially in Europe, offer hyperthermia therapy for Lyme, it remains controversial and lacks widespread support from mainstream medical guidelines due to limited clinical evidence.